Basic Information

Symbol
SEC62
RNA class
mRNA
Alias
SEC62 Preprotein Translocation Factor SEC62 Homolog, Preprotein Translocation Factor Translocation Protein 1 Dtrp1 TLOC1 HTP1 Translocation Protein SEC62 HTP-1 TP-1 Membrane Protein SEC62, S.Cerevisiae, Homolog Of SEC62 Homolog (S. Cerevisiae)
Location (GRCh38)
3:169966635-169998373
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003262.4
Sequence length
6526.0 nt
GC content
0.3652

Transcripts

ID Sequence Length GC content
NM_003262.4 NCBI
GGGCGGAGCGGCCAACAUGGCGGAACGCAGGAGACACAAGAAGCGGAUC… 6526 nt 0.3652
Summary

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly upregulated the SEC62 in cortical microglia, as part of a broader dysregulation of the protein processing of endoplasmic reticulum pathway [Oladapo et al. DOI:10.3390/Ijms26020649].