Basic Information

Symbol
SEL1L
RNA class
mRNA
Alias
SEL1L Adaptor Subunit Of SYVN1 Ubiquitin Ligase SEL1L1 Hrd3 SEL1L Adaptor Subunit Of ERAD E3 Ubiquitin Ligase SEL1L, ERAD E3 Ligase Adaptor Subunit Suppressor Of Lin-12-Like Protein 1 Protein Sel-1 Homolog 1 IBD2 Suppressor Of Lin 12 (Sel-1), C. Elegans, Homolog Of Sel-1 Suppressor Of Lin-12-Like 1 (C. Elegans) Sel-1 Suppressor Of Lin-12-Like (C. Elegans) Sel-1 Suppressor Of Lin-12-Like 1 SEL1-LIKE NEDGSAF NEDHGFA PRO1063 TSA305 Sel-1L
Location (GRCh38)
14:81471547-81533863
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005065.6
Sequence length
7919.0 nt
GC content
0.3934

Transcripts

ID Sequence Length GC content
NM_001244984.2 NCBI
AGGAGACUAGAGCAGGAAGAGCAGCGGCGAGGCGGCGGUGGUGGCUGAG… 1651 nt 0.4113
NM_005065.6 NCBI
AGGAGACUAGAGCAGGAAGAGCAGCGGCGAGGCGGCGGUGGUGGCUGAG… 7919 nt 0.3934
Summary

The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulated the SEL1L in microglia, where it was identified as a component of the protein processing of endoplasmic reticulum pathway [Oladapo et al. DOI:10.3390/Ijms26020649].