Basic Information

Symbol
SELENOS
RNA class
mRNA
Alias
Selenoprotein S SELS VCP-Interacting Membrane Protein AD-015 SBBI8 SEPS1 VIMP Valosin-Containing Protein-Interacting Membrane Protein VCP Interacting Membrane Selenoprotein MGC2553 ADO15 Tanis SelS
Location (GRCh38)
15:101270531-101277500
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_018445.6
Sequence length
1218.0 nt
GC content
0.4803

Transcripts

ID Sequence Length GC content
NM_018445.6 NCBI
AGGAGCGCACCGGAAGCGCCCGGCUGGAGGCGCGGCGGCAGGGCUGGGC… 1218 nt 0.4803
NM_203472.3 NCBI
AGGAGCGCACCGGAAGCGCCCGGCUGGAGGCGCGGCGGCAGGGCUGGGC… 1482 nt 0.5000
Summary

This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]

Forensic Context

No relevant information is available at the moment.