Basic Information

Symbol
SEMA3A
RNA class
mRNA
Alias
Semaphorin 3A Hsema-I Coll-1 SEMA1 SEMAD SemD Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3A Semaphorin III Semaphorin-3A Sema III Semaphorin D Semaphorin L Collapsin 1 Hsema-III SEMAIII COLL1 SEMAL HH16
Location (GRCh38)
7:83955777-84492939
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006080.3
Sequence length
8113.0 nt
GC content
0.3667

Transcripts

ID Sequence Length GC content
NM_006080.3 NCBI
GAGGGUUUGAAGUUUCUGUGCUUCAGUGACUGUUACAGAAGAAGAGGUG… 8113 nt 0.3667
Summary

This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human dermal lymphatic endothelial cells (LECs) identified the SEMA3A as a potential downstream target of the LEC-specific lncRNA LETR1 via Chromatin Isolation by RNA Purification sequencing (ChIRP-Seq) [Ducoli et al. DOI:10.1038/s41467-021-21217-0].