Basic Information

Symbol
SEMA3E
RNA class
mRNA
Alias
Semaphorin 3E KIAA0331 M-SemaK Coll-5 SEMAH Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3E Semaphorin-3E M-Sema H M-SEMAH
Location (GRCh38)
7:83363238-83649139
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012431.3
Sequence length
7273.0 nt
GC content
0.3804

Transcripts

ID Sequence Length GC content
NM_001178129.2 NCBI
AAACUAAACAGUGUCCUAUAGGCAGCUAUCAGCUCAGCAUGUGUUGUUU… 6661 nt 0.3689
NM_012431.3 NCBI
AACCCUGCCUGAACUUUCCUGUAAACAGCCACUGACAGACUGCAUCCCU… 7273 nt 0.3804
Summary

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

Forensic Context

A study in human postmortem brain tissue from subjects with opioid use disorder (OUD) identified the SEMA3E as part of an angiogenesis pathway through gene ontology analysis, where it was correlated with specific cell types [Mendez et al. DOI:10.1038/s41380-021-01259-y].