Basic Information

Symbol
SEMA3F
RNA class
mRNA
Alias
Semaphorin 3F SEMAK Sema4 Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3F Semaphorin-3F Semaphorin IV Sema IV Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, 3F Semaphorin III/F Sema III/F SEMA-IV
Location (GRCh38)
3:50155012-50189075
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004186.5
Sequence length
3607.0 nt
GC content
0.6174

Transcripts

ID Sequence Length GC content
NM_001318798.2 NCBI
GAGCGCCCCGUCCCGCCGGCGGCCGCGAGACCAGAGCGAGCGAACGAAC… 3246 nt 0.6038
NM_001318800.2 NCBI
CUGACUGGUGCUCCCUCUCUUCCAUCUUGGGCUGUCUGCAUGUGUCUCA… 3543 nt 0.5961
NM_004186.5 NCBI
GAGCGCCCCUGAGCCUUCCCAUGGCCCGGGCUGGGGCCCGGGCCCUCGG… 3607 nt 0.6174
Summary

This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Forensic Context

A study in mice demonstrated that among seven candidate mRNA markers analyzed via qRT-PCR, the SEMA3F showed no significant differences in expression among the control, CO2 intoxication, combined high CO2/hypoxia, and hypoxia groups, indicating it was not a significant marker for differential diagnosis in this experimental model [Yatsushiro et al. DOI:10.1007/S12024-025-00981-1].