Basic Information

Symbol
SEMA4A
RNA class
mRNA
Alias
Semaphorin 4A CORD10 SEMAB SemB Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4A Semaphorin-4A Semaphorin-B FLJ12287 Sema B RP35 SEMB
Location (GRCh38)
1:156147366-156178869
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_022367.4
Sequence length
3242.0 nt
GC content
0.5716

Transcripts

ID Sequence Length GC content
NM_001193300.2 NCBI
AGAGAUGCGGUCGCCAUGGUGACUGAGGACCAGUGAGGCGGGAUGGGGU… 3437 nt 0.5749
NM_001193301.2 NCBI
ACUGAGAGACCGGAAAGCCUGGCAUUCCAGAGGGAGGGAAACGCAGCGG… 3127 nt 0.5702
NM_001193302.2 NCBI
AGUGCUGGCUUUGGCAUGAUGGGCACCUGGAGGGCCGCACUCCCGUUCC… 2975 nt 0.5684
NM_001370567.1 NCBI
AGAGCUCCCUGGUGACAGUCUGUGGCUGAGCAUGGCCCUCCCAGCCCUG… 3064 nt 0.5689
NM_001370568.1 NCBI
AGAGAUGCGGUCGCCAUGGUGACUGAGGACCAGUGAGGCGGGAUGGGGU… 3044 nt 0.5670
NM_001370569.1 NCBI
AGAGAUGCGGUCGCCAUGGUGACUGAGGACCAGUGAGGCGGGAUGGGGU… 3061 nt 0.5668
NM_001370571.1 NCBI
AGAGAUGCGGUCGCCAUGGUGACUGAGGACCAGUGAGGCGGGAUGGGGU… 3463 nt 0.5744
NM_022367.4 NCBI
AGUGCUGGCUUUGGCAUGAUGGGCACCUGGAGGGCCGCACUCCCGUUCC… 3242 nt 0.5716
Summary

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

Forensic Context

A study in human myocardial biopsies from patients with dilated cardiomyopathy demonstrated that SEMA4A mRNA is upregulated in ischemic cardiomyopathy compared to volume overload cardiomyopathy and forms a negatively correlated pair with miR-218-5p, with their direct interaction validated by luciferase reporter assays [Bonet et al. DOI:10.3390/biom14050524]. In human sepsis patients, bioinformatics and validation analyses identified SEMA4A as a ligand for the PLXNB2 receptor within the SEMA4 signaling pathway, which is active in monocytes and associated with clinical outcomes [Liu et al. DOI:10.1590/1414-431X2025e14930].