Basic Information

Symbol
SEMA4D
RNA class
mRNA
Alias
Semaphorin 4D CD100 C9orf164 Coll-4 SEMAJ Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4D Semaphorin-4D FLJ39737 BB18 GR3 A8 Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, 4D Chromosome 9 Open Reading Frame 164 CD100 Antigen M-Sema G M-Sema-G COLL4
Location (GRCh38)
9:89360787-89498167
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001371194.2
Sequence length
4562.0 nt
GC content
0.5349

Transcripts

ID Sequence Length GC content
NM_006378.4 NCBI
GGCAACCCGCUCGGGUCCCCUUCCACACUGUGGAAGCUUUGUUCUUUCG… 4824 nt 0.5218
Showing 11 to 11 of 11 entries
Summary

Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; regulation of neuron projection development; and regulation of primary metabolic process. Located in microtubule organizing center; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human sepsis patients demonstrated that monocytes were decreased in non-survivors and functioned as key signal transmitters and receivers, with 25 associated signaling pathways identified including the SEMA4 pathway [Liu et al. DOI:10.1590/1414-431X2025e14930].