Basic Information

Symbol
SERPINA10
RNA class
mRNA
Alias
Serpin Family A Member 10 PZI ZPI Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10 Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10 Protein-Z Dependent Proteinase Inhibitor Protein Z-Dependent Protease Inhibitor PZ-Dependent Protease Inhibitor Serpin A10
Location (GRCh38)
14:94278767-94293295
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001100607.3
Sequence length
4970.0 nt
GC content
0.4143

Transcripts

ID Sequence Length GC content
NM_001100607.3 NCBI
GAAGGUUCUGGGCUGCAAAGCUGAAGCUUUGGUUUCUGCUCUAAAUGAA… 4970 nt 0.4143
NM_016186.3 NCBI
ACUCCACAGGGACUGUACAUACAGAUUGGGAGCUGGAGUGGGGUAAGAG… 5338 nt 0.4247
Summary

The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]

Forensic Context

A multi-center prospective multi-omics study in humans identified the protein SERPINA10 as an early warning marker for severe burn-associated sepsis, with validation in 45 patients showing it was statistically different between non-sepsis and sepsis groups on Burn-day 1 [Huang et al. DOI:10.1093/burnst/tkac050].