Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| ACUACUCCAGACAGACGGCUUUGGAAUCCACCAGCUACAUCCAGCUCCC… | 1576 nt | 0.5317 | |
| ACUACUCCAGACAGACGGCUUUGGAAUCCACCAGCUACAUCCAGCUCCC… | 1668 nt | 0.5300 | |
| ACUACUCCAGACAGACGGCUUUGGAAUCCACCAGCUACAUCCAGCUCCC… | 1599 nt | 0.5335 | |
| ACUACUCCAGACAGACGGCUUUGGAAUCCACCAGCUACAUCCAGCUCCC… | 1780 nt | 0.5343 |
Summary
The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jun 2020]
Forensic Context
A study in rhesus macaques demonstrated that whole-thorax irradiation induced radiation-induced lung injury, with the SERPINA3 identified as the top upregulated transcript in irradiated lungs and its protein levels significantly increased in bronchoalveolar lavage fluid at 9.4 weeks post-irradiation, indicating its role as a biomarker of extracellular matrix remodeling [Priyanka Thakur et al. DOI:10.1016/j.ijrobp.2021.03.058]. A study in rhesus macaques demonstrated that the SERPINA3 was the top upregulated transcript in irradiated lungs and its protein levels were significantly increased in bronchoalveolar lavage fluid at 9.4 weeks post-irradiation, identifying it as a biomarker of extracellular matrix remodeling in radiation-induced lung injury [Thakur et al. DOI:10.1016/j.ijrobp.2021.03.058]. A systematic literature review in forensic medicine identifies the SERPINA3 as one of several studied vitality markers used to assess wound vitality [Pennisi et al. DOI:10.1007/s12024-022-00551-9].