Basic Information

Symbol
SERPINA4
RNA class
mRNA
Alias
Serpin Family A Member 4 KST Kallistatin KLST KAL PI4 Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4 Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4 Sserpin Family A Member 4 Peptidase Inhibitor 4 Kallikrein Inhibitor Serpin A4 PI-4 Protease Inhibitor 4 (Kallistatin) Testicular Secretory Protein Li 22
Location (GRCh38)
14:94561390-94570482
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006215.4
Sequence length
1665.0 nt
GC content
0.5471

Transcripts

ID Sequence Length GC content
NM_001289032.2 NCBI
AAGACAGAGCUGAGACAGCCACCCAGGGGGUCCACUCCAGGACAGACUG… 1980 nt 0.5460
NM_001289033.2 NCBI
AAGACAGAGCUGAGACAGCCACCCAGGGGGUCCACUCCAGGACAGACUG… 1825 nt 0.5414
NM_006215.4 NCBI
AAGACAGAGCUGAGACAGCCACCCAGGGGGUCCACUCCAGGACAGACUG… 1665 nt 0.5471
Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Located in extracellular exosome. Biomarker of diabetic retinopathy. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans demonstrated that the SERPINA4 is a plasma protein discriminant of disease severity in alcohol-associated hepatitis, exhibiting large abundance shifts between severe and nonsevere disease states and correlating with clinical severity scores [Argemi et al. DOI:10.1016/J.Ajpath.2022.08.009].