Basic Information

Symbol
SERPINB9
RNA class
mRNA
Alias
Serpin Family B Member 9 CAP3 Cytoplasmic Antiproteinase 3 PI9 Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 9 Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 Peptidase Inhibitor 9 Serpin B9 CAP-3 PI-9 Serpin Peptidase Inhibitor, Clade B, Member 9 Protease Inhibitor 9 (Ovalbumin Type) Testicular Tissue Protein Li 180
Location (GRCh38)
6:2887169-2903309
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004155.6
Sequence length
4143.0 nt
GC content
0.4352

Transcripts

ID Sequence Length GC content
NM_004155.6 NCBI
GGGAGUCCGCGGCGAGCGCAGCAGCAGGGCCGGGUCCUGCGCCUCGGGG… 4143 nt 0.4352
Summary

This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

Forensic Context

A study in mice demonstrated that SERPINB9 was upregulated in spleen leukocytes as part of a common early transcriptional response across three models of systemic inflammation (trauma/hemorrhage, burn injury, and LPS infusion) [Brownstein et al. DOI:10.1152/physiolgenomics.00213.2005].