Forensic Context

A study in human prostate tissue demonstrated that the SERPINE1 is upregulated in samples with a high postmortem interval (PMI) and is involved in enzyme and protease binding molecular functions [Javan et al. DOI:10.1038/s41598-025-29561-7]. In rhesus macaques, the SERPINE1 was identified as a differentially expressed gene upregulated in animals with hypertrophic cardiomyopathy [Rivas et al. DOI:10.1038/s41598-024-82770-4]. A study in rats demonstrated that the SERPINE1 mRNA expression was significantly increased in skin incision wound tissue at 1 and 3 days post-wounding, and its protein was localized to endothelial cells, fibroblasts, and leukocytes at the wound site [Kameyama et al. DOI:10.1016/J.Legalmed.2015.02.007]. In pediatric septic shock patients, plasma levels of the SERPINE1 were significantly elevated in a subclass characterized by worse clinical outcomes, innate immune upregulation, and endothelial injury [Yang et al. DOI:10.1186/s13054-023-04689-y].