Basic Information

Symbol
SERPINF2
RNA class
mRNA
Alias
Serpin Family F Member 2 AAP Alpha-2-Plasmin Inhibitor Alpha-2-Antiplasmin ALPHA-2-PI Alpha2AP A2AP API PLI Serine (Or Cysteine) Proteinase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 2 Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 2 Alpha-2-AP Serpin F2 Plasmin Inhibitor Alpha-2-PI
Location (GRCh38)
17:1742069-1755271
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000934.4
Sequence length
2249.0 nt
GC content
0.6141

Transcripts

ID Sequence Length GC content
NM_000934.4 NCBI
AGAGGAACGUUGUGUGUGGCAGCAAGGAGCCCGCAGAGGAACAUGGCGC… 2249 nt 0.6141
NM_001165920.1 NCBI
GGGACUUGAAAAACUGGAGCCUGUUCUUGGCAAGAAGAUUCUAAUGCCC… 2296 nt 0.6019
NM_001165921.2 NCBI
AGAGGAACGUUGUGUGUGGCAGCAAGGAGCCCGCAGAGGAACAUGGCGC… 2057 nt 0.6096
Summary

This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Forensic Context

A study in human blood plasma demonstrated that the SERPINF2 (alpha-2-antiplasmin) was significantly downregulated with age and was used as part of a 21-protein panel to build age-predictive models [Salignon et al. DOI:10.18632/aging.204787]. The protein-based model achieved an R² of 0.59 ± 0.02, and combining this proteomic data with miRNA data significantly improved prediction accuracy to an R² of 0.70 ± 0.01, capturing a broader range of age-related physiological changes.