Basic Information

Symbol
SERPING1
RNA class
mRNA
Alias
Serpin Family G Member 1 C1IN Plasma Protease C1 Inhibitor C1INH HAE1 HAE2 C1NH Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1 C1 Esterase Inhibitor C1-Inhibiting Factor C1-Inhibitor Serpin G1 C1-INH Serine (Or Cysteine) Proteinase Inhibitor, Clade G (C1 Inhibitor), Member 1, (Angioedema, Hereditary) Serine/Cysteine Proteinase Inhibitor Clade G Member 1 Serpin Peptidase Inhibitor Clade G Member 1 Epididymis Secretory Sperm Binding Protein Complement Component 1 Inhibitor Angioedema, Hereditary C1 Inh C1Inh
Location (GRCh38)
11:57597387-57619246
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000062.3
Sequence length
1830.0 nt
GC content
0.5415

Transcripts

ID Sequence Length GC content
NM_000062.3 NCBI
AGUCUGCACUGGAGCUGCCUGGUGACCAGAAGUUUGGAGUCCGCUGACG… 1830 nt 0.5415
NM_001032295.2 NCBI
AGGGUGGGAGCUGGCUCCGAGGCUGGCUGGCUCCGCAGGUCCGCUGACG… 1830 nt 0.5454
Summary

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its encoded protein, C1 inhibitor, inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. It is synthesized in the liver, and its deficiency is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, May 2020]

Forensic Context

A study in humans and mice demonstrated that serpin peptidase inhibitor clade G member 1 (SERPING1) was upregulated in serum exosomes from septic patients [Li et al. DOI:10.1016/j.jare.2021.11.005].