Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| GUCCGUGCUGACUGAGGCGCUGCAGCCAGGAGCCGCGGCCGGCUGCCCA… | 4806 nt | 0.3891 | |
| UGAAACAGCCUGUGGAUAUGCCCCCUCGAUUGUCUUGUCUUGUGAAAAC… | 4851 nt | 0.3752 | |
| GCUCCGCGGCCCAGCCUGGCGCUCGAGGAUUGCCAGGGCCGCCCUGUGC… | 5664 nt | 0.4059 |
Summary
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Forensic Context
A study in mice demonstrated that acute alcohol exposure during neurulation induces short-term transcriptomic changes in the rostroventral neural tube, with the SESN1 being up-regulated 2 hours post-exposure as part of the p53 signaling pathway response [Boschen et al. DOI:10.1016/J.Alcohol.2022.09.001]. In a rat model of asarum-induced hepatotoxicity, transcriptomic analysis similarly identified the SESN1 as upregulated, with integrated metabolomics linking its expression to perturbations in the p53 signaling pathway, amino acid metabolism, and bile acid biosynthesis [Cao et al. DOI:10.3892/Etm.2020.8811].