Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| AGUGAGCACAGAGCUCCUUGCCAGUAGGCGAUGCAAGUUAUCUCUGGGG… | 9279 nt | 0.3621 | |
| GCACUGAGGCGCUGCGGCGGCGGUGGUGGCGGUGGCAGCGGUGGCGGCU… | 9563 nt | 0.3714 |
Summary
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Forensic Context
A study in humans identified numerous mRNA markers in blood whose expression correlates with donor age, with lasso regression models achieving a mean absolute error of 4.46 years in one dataset [Dørum et al. DOI:10.1016/j.fsigen.2023.102976].