Basic Information

Symbol
SETD3
RNA class
mRNA
Alias
SET Domain Containing 3, Actin N3(Tau)-Histidine Methyltransferase C14orf154 SET Domain Containing 3, Actin Histidine Methyltransferase Protein-L-Histidine N-Tele-Methyltransferase Actin-Histidine N-Methyltransferase SET Domain-Containing Protein 3 FLJ23027 HSETD3 Histone-Lysine N-Methyltransferase Setd3 Chromosome 14 Open Reading Frame 154 SET Domain Containing 3 EC 2.1.1.85
Location (GRCh38)
14:99395061-99480927
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_032233.3
Sequence length
2856.0 nt
GC content
0.4510

Transcripts

ID Sequence Length GC content
NM_032233.3 NCBI
AGGCUGCCGUCCCGCCCCUCCCGUCCGGCCGCCGCCGCCGCCACCGCCG… 2856 nt 0.4510
NM_199123.2 NCBI
AGGCUGCCGUCCCGCCCCUCCCGUCCGGCCGCCGCCGCCGCCACCGCCG… 1401 nt 0.4918
Summary

Enables protein-L-histidine N-tele-methyltransferase activity. Involved in actin modification and peptidyl-histidine methylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human monozygotic twins demonstrated that the SETD3 is a target of miR-15b, which was validated as a biomarker associated with reduced physical function in activity of daily living strength scores [La Grotta et al. DOI:10.1016/j.mad.2025.112099].