Basic Information

Symbol
SF3B5
RNA class
mRNA
Alias
Splicing Factor 3b Subunit 5 SF3b10 Ysf3 Pre-MRNA-Splicing Factor SF3b 10 KDa Subunit Splicing Factor 3b, Subunit 5, 10kDa MGC3133 Splicing Factor 3B Subunit 5 SF3B10 SF3b5
Location (GRCh38)
6:144094884-144095573
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_031287.3
Sequence length
690.0 nt
GC content
0.5652

Transcripts

ID Sequence Length GC content
NM_031287.3 NCBI
ACUCUCCUGUAAAACGCUAGAGCGGCGAGUUGUUACCUGCGUCCUCUGA… 690 nt 0.5652
Summary

Enables RNA binding activity and splicing factor binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U12-type spliceosomal complex and U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that the SF3B5 was identified as an overlapping differentially expressed gene from a microarray study, located on proximal chromosome 10 and overexpressed in the methamphetamine high drinking (MAHDR) line [Hitzemann et al. DOI:10.3390/brainsci9070155]. In a separate study of human post-mortem tissues, the SF3B5 was found to be upregulated as part of the metabolism of RNA pathway in the colon of sepsis patients [Pinheiro da Silva et al. DOI:10.1111/jcmm.17938].