Basic Information

Symbol
SFI1
RNA class
mRNA
Alias
SFI1 Centrin Binding Protein KIAA0542 PPP1R139 PISD Protein Phosphatase 1, Regulatory Subunit 139 Protein SFI1 Homolog Sfi1 Homolog, Spindle Assembly Associated (Yeast) Sfi1 Homolog, Spindle Assembly Associated Homolog Of Yeast Sfi1 HSfi1p HSFI1
Location (GRCh38)
22:31488688-31618588
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001007467.3
Sequence length
4031.0 nt
GC content
0.5778

Transcripts

ID Sequence Length GC content
NM_001007467.3 NCBI
GAGGCGGGCGUGGACCGCGCGGGAGUUAAGAAGCAGGUCCCGGAUCGCC… 4031 nt 0.5778
NM_001258325.1 NCBI
GGAAGUGAGGGAGGGAGGACUUUCGUACGCAGCCGCCUCCCAGCUGGAA… 4226 nt 0.5925
NM_001258326.2 NCBI
GAGGCGGGCGUGGACCGCGCGGGAGUUAAGAAGCAGGUCCCGGAUCGCC… 3781 nt 0.5866
NM_001258327.2 NCBI
GAGGCGGGCGUGGACCGCGCGGGAGUUAAGAAGCAGGUCCCGGAUCGCC… 3749 nt 0.5879
NM_014775.4 NCBI
GAGGCGGGCGUGGACCGCGCGGGAGUUAAGAAGCAGGUCCCGGAUCGCC… 3938 nt 0.5808
Summary

Enables phosphatase binding activity. Located in centriole. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans identified the SFI1 as a diagnostic marker for sepsis via machine learning, where it was part of a five-gene diagnostic model that achieved an AUC of 0.987 on a validation set [Wang et al. DOI:10.3390/ijms26093993]. A study in humans demonstrated that the SFI1 gene was downregulated during long-term weight loss (0 to 12 months) in weight losers, as identified in subcutaneous adipose tissue from obese participants undergoing a one-year intervention [Bollepalli et al. DOI:10.1038/ijo.2017.245].