Basic Information

Symbol
SFRP5
RNA class
mRNA
Alias
Secreted Frizzled Related Protein 5 SARP3 Secreted Apoptosis Related Protein 3 Secreted Frizzled-Related Protein 5 Frizzled-Related Protein 1b FRP-1b SARP-3 SFRP-5 Secreted Apoptosis-Related Protein 3 FRP1B
Location (GRCh38)
10:97766751-97771999
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003015.3
Sequence length
1883.0 nt
GC content
0.6320

Transcripts

ID Sequence Length GC content
NM_003015.3 NCBI
AGUCGGGGCGCCCGCAGCGCAGGCUGCCACCCACCUGGGCGACCUCCGC… 1883 nt 0.6320
Summary

Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]

Forensic Context

A study in Sprague-Dawley rats demonstrated that the mRNA encoding the SFRP5 exhibited a specific temporal expression pattern in injured skeletal muscle, decreasing initially and then gradually increasing toward basal levels, with its lowest expression at 20 hours post-contusion [Zhu et al. DOI:10.1016/j.jflm.2016.07.013].