Basic Information

Symbol
SFTA2
RNA class
mRNA
Alias
Surfactant Associated 2 SP-G SFTPG Surfactant Associated Protein G Surfactant-Associated Protein 2 Surfactant-Associated Protein G GSGL541 UNQ541
Location (GRCh38)
6:30931353-30955636
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Mixture deconvolution
External database
HGNC NCBI Ensembl UniProt GTEx

MANE select

Transcript ID
NM_205854.3
Sequence length
446.0 nt
GC content
0.5561

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-155.7 kcal/mol
Thermodynamic ensemble
Free energy: -163.19 kcal/mol
Frequency: 0.0000
Diversity: 82.87
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..........(((.(((.(((((.((((((.(((((......)))))((((......))))....)))))).....(((((((((((((((....(((........))).......)))))))....((((((((((.((((.....((((((.......)).))))(((.((((((.....((((((......((((...))))...))))))....))))))))).((((((((((.(((((((.....(((((....))).))........((((.((...(((((...)))))))))))..........(((...((((((((.(((......))).))))))))..))).))))))).)))))).)))))))).))))))..)))).))))))))....))))).)))))).........(((((((....)))))))...
Thermodynamic Ensemble Prediction
..........(((.(((.(((((.((((((.(((((......)))))((((......))))....)))))).....(((((((((((((((....(((........))).......))))))),...{(((((((((.((((.....{(({{{....,,,)}.|}||(((.({((({.,.|.{{{{{(,,....{||{.||}}}}..,)))}))|,,.}}}))))}},((((((((((.(((((((,...,(((((..,,}||.}},.......(((,,((...((((,...})))))))))).....,,...(((...{(((((((.(|(|.....))|,)))))))).,))).))))))).)))))).)))))))).)))))).,}))}.})))))))....))))).)))))).........(((((((....)))))))...

Transcripts

ID Sequence Length GC content
NM_205854.3 NCBI
GUAGAAACAGGCCUGUUAAGGAGAGGCCACCGGGACUUCAGUGUCUCCU… 446 nt 0.5561
Summary

Predicted to be located in Golgi apparatus; extracellular region; and transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans identified the SFTA2 as a putative mRNA biomarker for vaginal secretions, where it was expressed at higher levels in vaginal secretions compared to saliva with an average 29-fold difference, though it showed cross-reactivity with saliva in 5 out of 15 samples tested [Hanson et al. DOI:10.1016/j.scijus.2012.03.007]. Subsequent research established a coding single nucleotide polymorphism (cSNP) typing system for vaginal secretions, incorporating the SFTA2 gene, which contains cSNPs rs2286656 and rs4713402, and demonstrated that this system could identify the donor of vaginal secretions in mixture stains with high sensitivity and specificity [Zhang et al. DOI:10.1016/j.fsigen.2022.102703].