Basic Information

Symbol
SFTPA2
RNA class
mRNA
Alias
Surfactant Protein A2 COLEC5 SP-A2 35 KDa Pulmonary Surfactant-Associated Protein Surfactant, Pulmonary-Associated Protein A2A Pulmonary Surfactant-Associated Protein A2 Alveolar Proteinosis Protein SFTPA2B PSP-A SFTP1 PSAP PSPA SP-A Surfactant, Pulmonary-Associated Protein A2 Collectin 5 Collectin-5 SP-2A SPAII SFTPA ILD2 SPA2
Location (GRCh38)
10:79555761-79560492
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001098668.4
Sequence length
2201.0 nt
GC content
0.5320

Transcripts

ID Sequence Length GC content
NM_001098668.4 NCBI
AACUUGGAGGCAGAGACCCAAGCAGCUGGAGGCUCUGUGUGUGGGUCGC… 2201 nt 0.5320
NM_001320813.2 NCBI
AACUUGGAGGCAGAGACCCAAGCAGCUGGAGGCUCUGUGUGUGGGUCGC… 2204 nt 0.5322
NM_001320814.1 NCBI
AGAGCAUGGAAGAUUCAGCUGAAAUCAGAGAGGUGAAGCCAGUUUCCCA… 2341 nt 0.5305
Summary

This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009]

Forensic Context

A study in human forensic autopsy cases demonstrated that SP-A2 mRNA levels, quantified using TaqMan real-time RT-PCR, were significantly lower in drowning, mechanical asphyxiation, fire fatality, and acute cardiac deaths compared to hypothermia and injury [Miyazato et al. DOI:10.1007/S00414-012-0698-2]. A study in rats demonstrated that intra-alveolar granular staining of the SFTPA2 was more severe in drowned lungs compared to postmortem submersion and control groups, suggesting its decreased expression could be a marker for drowning diagnosis [Lee et al. DOI:10.1111/1556-4029.13347].