Basic Information

Symbol
SFTPC
RNA class
mRNA
Alias
Surfactant Protein C SP-C BRICD6 PSP-C SMDP2 SFTP2 Pulmonary Surfactant-Associated Proteolipid SPL(Val) BRICHOS Domain Containing 6 SP5 Surfactant, Pulmonary-Associated Protein C Pulmonary Surfactant-Associated Protein C Pulmonary Surfactant Apoprotein-2 SP-C
Location (GRCh38)
8:22156913-22164479
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001317778.2
Sequence length
839.0 nt
GC content
0.6079

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-340.5 kcal/mol
Thermodynamic ensemble
Free energy: -353.94 kcal/mol
Frequency: 0.0000
Diversity: 170.41
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((((........((((..((((((....((((((......((((..(((((((..((.((((..((.(((....))))).)))))))))))))..))))))))))..))))))...))))....(((.....))).....(((((((((((((((.((((((..((((.((((.(((((((.((((((((((....((((((...((((((....(....)....)))))))))))))))))...)))))........)))).)))))))))))..)))).)).)))).....)))))))))))))))))).))(((((((((((((..(((((.....)))))((((....))))...........(((((...))))).....(((((.((((.((..(((.((((....)))))))..)).....(((((..((.(((((.((((.....))))...(((((.(((((...(((((..(((((...))))).)))))((((((((((.......))).)).))))).((((((.......))))))))))).)))))(((.(((((.(((...))).)))))))).........))))))).))))).)))))))))))))))))).)))).(((((((.........(((((((((.....((((((((((.....)))))).)))).....(((((((((((((((.((((.....(((((((((......)))).))))).......).)))..))))))))))))))))))).))))).((((....))))...................)))).))).........
Thermodynamic Ensemble Prediction
(((((((((...((...((....||.||.{(.,(,{{.((((((((({{..(((((((..((.((((..(,{(((....))))).)))))))))))))..}},||...,},,))))))))}}},)}.,,,....,,,,}}.....(((((((((((((((.((((((..((((.((((.(((({((.((((((((({...,((((((...((((((....(....)....)))))))))))))))))}..})))).,,.....})),})))))))))))..)))).)).)))).....)))))))))))))))))).}}(((((((((((((((((((((({.......((((((.{(({,...{|......{{{{|,..})))),.}}))))})))))))))}.(((.((((....))))))),,{{....,|.}}{{((((((.((...((((..........(((((.(((({...{((((..((((,...))))).))))}((((((((((.......))).)).))))).((((((.......)))))),)))).)))))(((.(((((.(((...))).)))))))).............))))...)).)))))).}))))))))))},))).{,,{(((...{,....,{(((((((...,,((({{{(((({...|)))))).}}}).....(((((((((((((((.((((.....(((((((({......)))).))))).......}.)))..))))))))))))))))))).}}}))}}|||...,))}||..,..,,,......,,,.}))).))).........

Transcripts

ID Sequence Length GC content
NM_001172357.2 NCBI
GAGGAGAGGAGAGCAUAGCACCUGCAGCAAGAUGGAUGUGGGCAGCAAA… 1045 nt 0.6163
NM_001172410.2 NCBI
GAGGAGAGGAGAGCAUAGCACCUGCAGCAAGAUGGAUGUGGGCAGCAAA… 849 nt 0.6054
NM_001317778.2 NCBI
GAGGAGAGGAGAGCAUAGCACCUGCAGCAAGAUGGAUGUGGGCAGCAAA… 839 nt 0.6079
NM_001317779.2 NCBI
GAGGAGAGGAGAGCAUAGCACCUGCAGCAAGAUGGAUGUGGGCAGCAAA… 698 nt 0.6074
NM_001317780.2 NCBI
GAGGAGAGGAGAGCAUAGCACCUGCAGCAAGAUGGAUGUGGGCAGCAAA… 831 nt 0.6077
NM_001385653.1 NCBI
GAGGAGAGGAGAGCAUAGCACCUGCAGCAAGAUGGAUGUGGGCAGCAAA… 859 nt 0.6054
NM_001385654.1 NCBI
AGUCCAGCCCUUUGUCUAACAAAUGAGGAAACUGAGGCCCCCUAAGCUU… 1545 nt 0.5825
NM_001385655.1 NCBI
AGUCCAGCCCUUUGUCUAACAAAUGAGGAAACUGAGGCCCCCUAAGCUU… 1553 nt 0.5827
NM_001385656.1 NCBI
AGUCCAGCCCUUUGUCUAACAAAUGAGGAAACUGAGGCCCCCUAAGCUU… 1741 nt 0.5916
NM_001385657.1 NCBI
AGUCCAGCCCUUUGUCUAACAAAUGAGGAAACUGAGGCCCCCUAAGCUU… 1527 nt 0.5835
Showing 1 to 10 of 14 entries
Summary

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010]

Forensic Context

A study in mice demonstrated that hyperoxia exposure significantly downregulated the SFTPC mRNA level, indicating a serious risk for pulmonary collapse and emphysema due to alveolar dysfunction [Shimada et al. DOI:10.1007/S00414-008-0226-6]. In human forensic science, the SFTPC was evaluated as a candidate mRNA marker for lung tissue identification within a multiplex assay designed to infer organ origin from crime scene samples, though it was not selected for the final validated panel [Lindenbergh et al. DOI:10.1007/s00414-013-0895-7]. In nonhuman primates, immunohistochemistry for the SFTPC was used as a type II pneumocyte marker to identify cell types expressing the cell cycle arrest protein p21 in radiation-induced lung injury [Thakur et al. DOI:10.1016/j.ijrobp.2021.03.058].