Basic Information

Symbol
SFTPC
RNA class
mRNA
Alias
Surfactant Protein C SP-C BRICD6 PSP-C SMDP2 SFTP2 Pulmonary Surfactant-Associated Proteolipid SPL(Val) BRICHOS Domain Containing 6 SP5 Surfactant, Pulmonary-Associated Protein C Pulmonary Surfactant-Associated Protein C Pulmonary Surfactant Apoprotein-2 SP-C
Location (GRCh38)
8:22156913-22164479
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001317778.2
Sequence length
839.0 nt
GC content
0.6079

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-340.5 kcal/mol
Thermodynamic ensemble
Free energy: -353.94 kcal/mol
Frequency: 0.0000
Diversity: 170.41
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((((........((((..((((((....((((((......((((..(((((((..((.((((..((.(((....))))).)))))))))))))..))))))))))..))))))...))))....(((.....))).....(((((((((((((((.((((((..((((.((((.(((((((.((((((((((....((((((...((((((....(....)....)))))))))))))))))...)))))........)))).)))))))))))..)))).)).)))).....)))))))))))))))))).))(((((((((((((..(((((.....)))))((((....))))...........(((((...))))).....(((((.((((.((..(((.((((....)))))))..)).....(((((..((.(((((.((((.....))))...(((((.(((((...(((((..(((((...))))).)))))((((((((((.......))).)).))))).((((((.......))))))))))).)))))(((.(((((.(((...))).)))))))).........))))))).))))).)))))))))))))))))).)))).(((((((.........(((((((((.....((((((((((.....)))))).)))).....(((((((((((((((.((((.....(((((((((......)))).))))).......).)))..))))))))))))))))))).))))).((((....))))...................)))).))).........
Thermodynamic Ensemble Prediction
(((((((((...((...((....||.||.{(.,(,{{.((((((((({{..(((((((..((.((((..(,{(((....))))).)))))))))))))..}},||...,},,))))))))}}},)}.,,,....,,,,}}.....(((((((((((((((.((((((..((((.((((.(((({((.((((((((({...,((((((...((((((....(....)....)))))))))))))))))}..})))).,,.....})),})))))))))))..)))).)).)))).....)))))))))))))))))).}}(((((((((((((((((((((({.......((((((.{(({,...{|......{{{{|,..})))),.}}))))})))))))))}.(((.((((....))))))),,{{....,|.}}{{((((((.((...((((..........(((((.(((({...{((((..((((,...))))).))))}((((((((((.......))).)).))))).((((((.......)))))),)))).)))))(((.(((((.(((...))).)))))))).............))))...)).)))))).}))))))))))},))).{,,{(((...{,....,{(((((((...,,((({{{(((({...|)))))).}}}).....(((((((((((((((.((((.....(((((((({......)))).))))).......}.)))..))))))))))))))))))).}}}))}}|||...,))}||..,..,,,......,,,.}))).))).........

Transcripts

ID Sequence Length GC content
NM_001385658.1 NCBI
AGUCCAGCCCUUUGUCUAACAAAUGAGGAAACUGAGGCCCCCUAAGCUU… 1535 nt 0.5837
NM_001385659.1 NCBI
ACACAGAAGGGGUGGCCACCGUGGGGCUGUCCAUCACUCAGGGCUCUCA… 1322 nt 0.5998
NM_001385660.1 NCBI
AGUCCAGCCCUUUGUCUAACAAAUGAGGAAACUGAGGCCCCCUAAGCUU… 1394 nt 0.5811
NM_003018.4 NCBI
GAGGAGAGGAGAGCAUAGCACCUGCAGCAAGAUGGAUGUGGGCAGCAAA… 857 nt 0.6056
Showing 11 to 14 of 14 entries
Summary

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010]

Forensic Context

A study in mice demonstrated that hyperoxia exposure significantly downregulated the SFTPC mRNA level, indicating a serious risk for pulmonary collapse and emphysema due to alveolar dysfunction [Shimada et al. DOI:10.1007/S00414-008-0226-6]. In human forensic science, the SFTPC was evaluated as a candidate mRNA marker for lung tissue identification within a multiplex assay designed to infer organ origin from crime scene samples, though it was not selected for the final validated panel [Lindenbergh et al. DOI:10.1007/s00414-013-0895-7]. In nonhuman primates, immunohistochemistry for the SFTPC was used as a type II pneumocyte marker to identify cell types expressing the cell cycle arrest protein p21 in radiation-induced lung injury [Thakur et al. DOI:10.1016/j.ijrobp.2021.03.058].