Basic Information

Symbol
SGCD
RNA class
mRNA
Alias
Sarcoglycan Delta CMD1L DAGD Sarcoglycan, Delta (35kDa Dystrophin-Associated Glycoprotein) 35 KDa Dystrophin-Associated Glycoprotein Delta-Sarcoglycan Delta-SG LGMD2F 35DAG Dystrophin Associated Glycoprotein, Delta Sarcoglycan Placental Delta Sarcoglycan SG-Delta LGMDR6 SGCDP SGD
Location (GRCh38)
5:155870344-156767788
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000337.6
Sequence length
9383.0 nt
GC content
0.4050

Transcripts

ID Sequence Length GC content
NM_000337.6 NCBI
AGAGCUGCUCAGCACGCCCUGGGAUCGCGGGCGGUUUUCAUCGGCCGGU… 9383 nt 0.4050
NM_001128209.2 NCBI
AGAGCUGCUCAGCACGCCCUGGGAUCGCGGGCGGUUUUCAUCGGCCGGU… 9337 nt 0.4043
NM_172244.3 NCBI
AGAGCUGCUCAGCACGCCCUGGGAUCGCGGGCGGUUUUCAUCGGCCGGU… 1166 nt 0.4425
Summary

The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans undergoing cardiac surgery with cardiopulmonary bypass demonstrated that acute left ventricular ischemia induces differential expression of 21 miRNAs, including upregulated miR-339-5p and downregulated miR-139-5p, with integrated mRNA analysis identifying anticorrelated miRNA-mRNA pairs [Saddic et al. DOI:10.1152/physiolgenomics.00049.2015].