Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| AACUGCUCUUCAGUGUGCCCUGAGCCGGCUGUGCCUUCUCUCCAUCCGC… | 3245 nt | 0.4687 | |
| AUAACAGAACAGGGAUAGCCGUCUCUGGCUCGUGCUCUCAUGUCAUCUC… | 2431 nt | 0.4373 | |
| GUCAGUGCUCGCCGGUCGCUCUCGUCUGCCGCGCGCCCCGCCGCCCGCU… | 2403 nt | 0.4532 | |
| GCAGCAUACGCCGAGCCGGUCUUUGAGCGCUAACGUCUUUCUGUCUCCC… | 2235 nt | 0.4403 | |
| GCAGCAUACGCCGAGCCGGUCUUUGAGCGCUAACGUCUUUCUGUCUCCC… | 2367 nt | 0.4406 |
Summary
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] CIViC Summary for SGK1 Gene
Forensic Context
A study in mice demonstrated that the SGK1 is downregulated in the corpus callosum-external capsule at 2 days post-traumatic brain injury [Kounelis-Wuillaume et al. DOI:10.1177/08977151251390528], while separate research in mice and human umbilical vein endothelial cells (HUVECs) investigating myocardial infarction noted that a lack of the SGK1 leads to impaired endothelial cell migration and angiogenesis, resulting in increased scarring and decreased angiogenesis in vivo after myocardial infarction [Wang & Dou DOI:10.1186/s12872-024-03727-z]. In human non-small-cell lung cancer, the SGK1 mRNA was identified as a target in a competing endogenous RNA network, where its expression was positively correlated with the lncRNA MIAT and negatively correlated with miR-133a-5p, and its expression was depressed by miR-133a-5p overexpression in A549 cells [Zheng et al. DOI:10.2147/CMAR.S163395].