Basic Information

Symbol
SGK3
RNA class
mRNA
Alias
Serum/Glucocorticoid Regulated Kinase Family Member 3 SGKL Serine/Threonine-Protein Kinase Sgk3 Cytokine-Independent Survival Kinase EC 2.7.11.1 CISK SGK2 Serum/Glucocorticoid Regulated Kinase Family, Member 3 Serum/Glucocorticoid Regulated Kinase-Like Serum/Glucocorticoid-Regulated Kinase-Like Serum/Glucocorticoid-Regulated Kinase 3 EC 2.7.11
Location (GRCh38)
8:66712484-66862022
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001033578.3
Sequence length
4106.0 nt
GC content
0.3731

Transcripts

ID Sequence Length GC content
NM_001033578.3 NCBI
GCAGUGCGUUCGGCUCCGCGCCCGCCGCGCCGGGAGCAGCACCGCGGGG… 4106 nt 0.3731
NM_013257.5 NCBI
AGGGAGCGCAGCUGGCGCCGCUGGGAGCUGGUGGCGCGGCGCAGGUCCC… 4168 nt 0.3781
NM_170709.3 NCBI
AGGGAGCGCAGCUGGCGCCGCUGGGAGCUGGUGGCGCGGCGCAGGUCCC… 4072 nt 0.3772
Summary

This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the SGK3 was upregulated in the dorsal raphe nucleus following passive MDMA administration compared to saline controls [Fernandez-Castillo et al. DOI:10.1111/J.1601-183X.2011.00735.X], while separate research in mouse cortical astrocytes showed that brief ethanol exposure significantly activated the SGK3 as part of a broader heat shock pathway response [Pignataro et al. DOI:10.1002/Brb3.125]. In a separate investigation of traumatic brain injury in mice, the SGK3 was found to be uniquely downregulated in the corpus callosum-external capsule at two days post-injury [Kounelis-Wuillaume et al. DOI:10.1177/08977151251390528].