Basic Information

Symbol
SGPP1
RNA class
mRNA
Alias
Sphingosine-1-Phosphate Phosphatase 1 Sphingosine-1-Phosphate Phosphohydrolase 1 Sphingosine-1-Phosphatase 1 HSPPase1 SPPase1 SPP-1 HSPP1 Spp1 EC 3.1.3.- EC 3.1.3 SPP1
Location (GRCh38)
14:63684216-63728065
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_030791.4
Sequence length
3336.0 nt
GC content
0.4059

Transcripts

ID Sequence Length GC content
NM_030791.4 NCBI
GUCACCCGGCAGACUCCGGAGGGUAGAGCGCUGUGCCGGUUCCGCUGCC… 3336 nt 0.4059
Summary

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]

Forensic Context

A study in human bone demonstrated that the protein OSTP_HUMAN showed a clear visual and significant negative trend with increasing postmortem interval, as identified through a multi-omics integration model for PMI estimation [Bonicelli et al. DOI:10.7554/eLife.83658]. A study in mice demonstrated that the monocyte/macrophage-associated gene SPP1 was significantly upregulated in myocardial tissues following acute myocardial infarction, as validated by qRT-PCR in an AMI mouse model [Yang et al. DOI:10.2147/JIR.S516092].