Basic Information

Symbol
SH2B2
RNA class
mRNA
Alias
SH2B Adaptor Protein 2 APS Adapter Protein With Pleckstrin Homology And Src Homology 2 Domains SH2 And PH Domain-Containing Adapter Protein APS SH2B Adapter Protein 2 Adaptor Protein With Pleckstrin Homology And Src
Location (GRCh38)
7:102284995-102321712
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001359228.2
Sequence length
2236.0 nt
GC content
0.7008

Transcripts

ID Sequence Length GC content
NM_001359228.2 NCBI
GCGCCGCGCUGGGGCUGGGCUUGGAGCGCGCGGAGCUCGGCUGCCAGAG… 2236 nt 0.7008
NM_001359229.2 NCBI
GCAGAGGACAGGCAGGAGUUGGAGGAAGAGGAUGUAUUUGAACUUGGAU… 2061 nt 0.6841
NM_001359230.2 NCBI
GCGCCGCGCUGGGGCUGGGCUUGGAGCGCGCGGAGCUCGGCUGCCAGAG… 2233 nt 0.7009
NM_001359231.2 NCBI
GCAGAGGACAGGCAGGAGUUGGAGGAAGAGGAUGUAUUUGAACUUGGAU… 2058 nt 0.6842
NM_001393990.3 NCBI
ACUUCUUCCUCCCUGGGGAUGGAUCCAAGCUAUUGUCCUGCCCAUGGCU… 2124 nt 0.6822
NM_001393991.3 NCBI
ACUUCUUCCUCCCUGGGGAUGGAUCCAAGCUAUUGUCCUGCCCAUGGCU… 2121 nt 0.6818
NM_001393992.3 NCBI
ACUUCUUCCUCCCUGGGGAUGGAUCCAAGCUAUUGUCCUGCCCAUGGCU… 2118 nt 0.6818
NM_001393993.1 NCBI
GCGCCGCGCUGGGGCUGGGCUUGGAGCGCGCGGAGCUCGGCUGCCAGAG… 2230 nt 0.7004
NM_001393994.1 NCBI
GCAGAGGACAGGCAGGAGUUGGAGGAAGAGGAUGUAUUUGAACUUGGAU… 2055 nt 0.6837
NM_001393995.1 NCBI
ACUUCUUCCUCCCUGGGGAUGGAUCCAAGCUAUUGUCCUGCCCAUGGCU… 1369 nt 0.6589
Showing 1 to 10 of 11 entries
Summary

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]

Forensic Context

No relevant information is available at the moment.