Basic Information
Symbol
SH2B2
RNA class
mRNA
Alias
SH2B Adaptor Protein 2
APS
Adapter Protein With Pleckstrin Homology And Src Homology 2 Domains
SH2 And PH Domain-Containing Adapter Protein APS
SH2B Adapter Protein 2
Adaptor Protein With Pleckstrin Homology And Src
Location (GRCh38)
7:102284995-102321712
Forensic tag(s)
-
MANE select
Transcript ID
NM_001359228.2
Sequence length
2236.0 nt
GC content
0.7008
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| ACUUCUUCCUCCCUGGGGAUGGAUCCAAGCUAUUGUCCUGCCCAUGGCU… | 2127 nt | 0.6822 |
Showing 11 to 11 of 11 entries
Summary
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]
Forensic Context
No relevant information is available at the moment.