Basic Information

Symbol
SH2D3C
RNA class
mRNA
Alias
SH2 Domain Containing 3C NSP3 SH2 Domain-Containing Eph Receptor-Binding Protein 1 Cas/HEF1-Associated Signal Transducer SH2 Domain-Containing Protein 3C Novel SH2-Containing Protein 3 Chat-H SHEP1 SH2 Domain-Containing 3C PRO34088 CHAT
Location (GRCh38)
9:127738317-127778727
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_170600.3
Sequence length
3051.0 nt
GC content
0.6083

Transcripts

ID Sequence Length GC content
NM_001142531.1 NCBI
ACACAAGUUGUAGAUGGCCUUCAGAUAUCCAAGGGGAGGCGUCCAGGAG… 2557 nt 0.6101
NM_001142532.1 NCBI
AGAUAUCCAAGGGGAGGCGUCCAGGAGGUAGUUGGGUUUCCAAGUCUGG… 2806 nt 0.6119
NM_001142533.1 NCBI
CCCGCUCCUCCCCCGACAAGGCGAUGAGGUAAUCGCGCCGCUGAGAGGC… 2694 nt 0.6229
NM_001142534.1 NCBI
GAUGAGGUAAUCGCGCCGCUGAGAGGCACGCGCAGCCGGUGCCUAGCCG… 2666 nt 0.6215
NM_001252334.2 NCBI
GAGAAAGGCAGGAGCCGCUGGGUUUAGGAGGUCCCCGGGUUGCCGGCGG… 2977 nt 0.6191
NM_005489.4 NCBI
GAGAAAGGCAGGAGCCGCUGGGUUUAGGAGGUCCCCGGGUUGCCGGCGG… 2606 nt 0.6186
NM_170600.3 NCBI
ACUCGCAAGCUGGCCAAGGGCUUCACACAAUUUGCCAAGAUGACAGAGG… 3051 nt 0.6083
Summary

This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Forensic Context

A study in humans demonstrated that the SH2D3C is an adapter protein mediating cell signaling for adhesion, migration, and immune response, and its expression shows a down-regulated pattern after death, where it was included in a post-mortem interval (PMI) prediction model with a negative coefficient [Antiga et al. DOI:10.1038/s41598-021-96095-z]. In a separate human study on myocardial ischaemia reperfusion injury, the SH2D3C mRNA was identified as a potential transcriptional regulator significantly enriched in the cellular response to stress, presented a negative correlation with injury, and its down-regulation reduced cardiac microvascular endothelial cell viability in an *in vitro* hypoxia/reoxygenation model [Liu et al. DOI:10.1111/jcmm.14163].