Basic Information

Symbol
SH3BGRL3
RNA class
mRNA
Alias
SH3 Domain Binding Glutamate Rich Protein Like 3 SH3 Domain Binding Glutamic Acid-Rich Protein Like 3 SH3 Domain-Binding Glutamic Acid-Rich-Like Protein 3 SH3 Domain-Binding Protein 1 TNF Inhibitory Protein B1 SH3BP-1 TIP-B1 Epididymis Secretory Sperm Binding Protein Epididymis Secretory Protein Li 297 TNF Inhibitory Protein SH3BGRL3-Like Protein HEL-S-297
Location (GRCh38)
1:26280057-26281522
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_031286.4
Sequence length
751.0 nt
GC content
0.5912

Transcripts

ID Sequence Length GC content
NM_031286.4 NCBI
GUCGUCUCCCGGCAGUGCAGCUGCCGCUACCGCCGCCCUCUGCCCGCCG… 751 nt 0.5912
Summary

Involved in cytoskeleton organization. Located in cytosol; nuclear body; and ruffle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans demonstrated that the SH3BGRL3 is a highly expressed transcript in platelets isolated from patients with acute myocardial infarction [Eicher et al. DOI:10.3109/09537104.2015.1083543]. In a separate human study analyzing subcutaneous adipose tissue, the SH3BGRL3 was identified as part of a 38-gene obesity signature, with a positive coefficient of 0.0457, and the overall signature correlated strongly with body mass index and fat mass, indicating its expression alterations are associated with environment and lifestyle rather than genetic background [Font-Clos et al. DOI:10.1088/1361-6579/aab85a].