Basic Information

Symbol
SH3GLB1
RNA class
mRNA
Alias
SH3 Domain Containing GRB2 Like, Endophilin B1 Bif-1 KIAA0491 PPP1R70 CGI-61 Protein Phosphatase 1, Regulatory Subunit 70 SH3 Domain-Containing GRB2-Like Protein B1 Bax-Interacting Factor 1 Endophilin-B1 SH3-Domain, GRB2-Like, Endophilin B1 SH3-Domain GRB2 Like Endophilin B1 Testicular Tissue Protein Li 172 SH3-Containing Protein SH3GLB1 DJ612B15.2
Location (GRCh38)
1:86704520-86748184
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_016009.5
Sequence length
6371.0 nt
GC content
0.3944

Transcripts

ID Sequence Length GC content
NM_001206651.2 NCBI
GUUUUUCCCUUGGGACCCGGGUCCACACGGCGGGGUCGCCCGUCCAUCU… 6458 nt 0.3944
NM_001206652.2 NCBI
GUUUUUCCCUUGGGACCCGGGUCCACACGGCGGGGUCGCCCGUCCAUCU… 6434 nt 0.3948
NM_001206653.2 NCBI
GUUUUUCCCUUGGGACCCGGGUCCACACGGCGGGGUCGCCCGUCCAUCU… 6229 nt 0.3946
NM_001410824.1 NCBI
GUUUUUCCCUUGGGACCCGGGUCCACACGGCGGGGUCGCCCGUCCAUCU… 6410 nt 0.3945
NM_016009.5 NCBI
GUUUUUCCCUUGGGACCCGGGUCCACACGGCGGGGUCGCCCGUCCAUCU… 6371 nt 0.3944
Summary

This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Forensic Context

A study in rat organotypic hippocampal slice cultures demonstrated that the SH3GLB1 was downregulated at 24 hours following a mild (10% Lagrangian stretch) traumatic brain injury, as identified through microarray analysis [Di Pietro et al. DOI:10.1089/neu.2009.1095]. This downregulation was part of a coordinated transcriptional response involving other genes associated with apoptotic processes, indicating its role in the cellular mechanisms activated early after neuronal stretch injury.