Basic Information

Symbol
SHANK1
RNA class
mRNA
Alias
SH3 And Multiple Ankyrin Repeat Domains 1 SSTRIP Somatostatin Receptor-Interacting Protein SPANK-1 Synamon SH3 And Multiple Ankyrin Repeat Domains Protein 1 SSTR-Interacting Protein Shank1
Location (GRCh38)
19:50659255-50719802
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_016148.5
Sequence length
9636.0 nt
GC content
0.6623

Transcripts

ID Sequence Length GC content
NM_016148.5 NCBI
AGAGACAGCGAGAGCGAGAGAGCGAGAAGGGUGGCAGAGGAGGCGCGGA… 9636 nt 0.6623
Summary

This gene encodes a member of the SHANK (SH3 domain and ankyrin repeat containing) family of proteins. Members of this family act as scaffold proteins that are required for the development and function of neuronal synapses. Deletions in this gene may be associated with autism spectrum disorder in males. [provided by RefSeq, Apr 2016]

Forensic Context

A study in mice demonstrated that the SHANK1 gene, a protein-coding gene, was identified as a differentially wired (DW) gene enriched in synapse part annotation within the prefrontal cortex of selectively bred lines with differential risk for voluntary methamphetamine intake [Hitzemann et al. DOI:10.3390/brainsci9070155].