Basic Information

Symbol
SHBG
RNA class
mRNA
Alias
Sex Hormone Binding Globulin ABP Sex Hormone-Binding Globulin TEBG Testis-Specific Androgen-Binding Protein Testosterone-Estradiol-Binding Globulin Testosterone-Estrogen-Binding Globulin Sex Steroid-Binding Protein MGC126834 MGC138391 SBP Testosterone-Binding Beta-Globulin Androgen Binding Protein TeBG
Location (GRCh38)
17:7613946-7633469
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001040.5
Sequence length
1267.0 nt
GC content
0.5880

Transcripts

ID Sequence Length GC content
NM_001040.5 NCBI
AAGAGUUGUCUGAGCCGCCGAGUGGACAGUGGCUGAUUAUGGAGAGCAG… 1267 nt 0.5880
NM_001146279.3 NCBI
AAGAGUUGUCUGAGCCGCCGAGUGGACAGUGGCUGAUUAUGGAGAGCAG… 1213 nt 0.5853
NM_001146280.3 NCBI
AAGAGUUGUCUGAGCCGCCGAGUGGACAGUGGCUGAUUAUGGAGAGCAG… 1059 nt 0.5836
NM_001146281.3 NCBI
AAGAGUUGUCUGAGCCGCCGAGUGGACAGUGGCUGAUUAUGGAGAGCAG… 922 nt 0.5835
NM_001289113.2 NCBI
AGUCUUCACCCGAAUCAGCCUCAGGAUAUCUCCACAGUCUCCCUCCUUG… 1709 nt 0.5974
NM_001289114.2 NCBI
AAUUCUCCAUGUGCUUGGAUCGUGGGGAAGAUGUGAUUAAGGUCUAAGU… 1164 nt 0.5782
NM_001289115.2 NCBI
AGUCUUCACCCGAAUCAGCCUCAGGAUAUCUCCACAGUCUCCCUCCUUG… 1501 nt 0.5956
NM_001289116.2 NCBI
AAGAGUUGUCUGAGCCGCCGAGUGGACAGUGGCUGAUUAUGGAGAGCAG… 1175 nt 0.5855
Summary

This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Forensic Context

A study in healthy young women demonstrated that serum sex hormone-binding globulin (SHBG) concentrations were significantly lower in heavier co-twins compared to their leaner monozygotic sisters, and these levels correlated inversely with intra-abdominal fat volume [Vihma et al. DOI:10.1016/j.steroids.2018.08.006].