Basic Information

Symbol
SHC2
RNA class
mRNA
Alias
SHC Adaptor Protein 2 SHCB SCK SLI SHC (Src Homology 2 Domain Containing) Transforming Protein 2 Src Homology 2 Domain-Containing-Transforming Protein C2 Neuronal Shc Adaptor Homolog SHC-Transforming Protein 2 SHC-Transforming Protein B SH2 Domain Protein C2 Protein Sck
Location (GRCh38)
19:416589-461100
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012435.3
Sequence length
2525.0 nt
GC content
0.6848

Transcripts

ID Sequence Length GC content
NM_001387056.1 NCBI
GCAGCGCCCGGUCGGGCUCCGUCGGGCGGCCGCGGCCAUGACGCAGGGU… 2390 nt 0.6849
NM_012435.3 NCBI
GCAGCGCCCGGUCGGGCUCCGUCGGGCGGCCGCGGCCAUGACGCAGGGU… 2525 nt 0.6848
Summary

Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans demonstrated that the gene SHC2 is involved in vascular regeneration and is enriched in the VEGF signaling pathway, showing upregulation at 3 months post-acute myocardial infarction (AMI) [Wang et al. DOI:10.1038/s41598-024-60945-3].