Basic Information

Symbol
SHISA5
RNA class
mRNA
Alias
Shisa Family Member 5 SCOTIN Putative NF-Kappa-B-Activating Protein 120 Protein Shisa-5 HShisa5 Shisa Homolog 5 (Xenopus Laevis) Shisa Homolog 5 Scotin
Location (GRCh38)
3:48467798-48504826
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_016479.6
Sequence length
2034.0 nt
GC content
0.5939

Transcripts

ID Sequence Length GC content
NM_001272065.3 NCBI
GGGCGGCCGCGCGGAUCACUGAGGCUGUGGCGGCACUGCGCCCGGCGCU… 2013 nt 0.5931
NM_001272066.2 NCBI
GCCAGUUUCUAGCUCAGUCCUGGCCCACUGCGCCAGCGCUGAGCCUGCC… 2059 nt 0.5838
NM_001272067.2 NCBI
GCCAGUUUCUAGCUCAGUCCUGGCCCACUGCGCCAGCGCUGAGCCUGCC… 2266 nt 0.5944
NM_001272068.2 NCBI
GGGCGGCCGCGCGGAUCACUGAGGCUGUGGCGGCACUGCGCCCGGCGCU… 2431 nt 0.6055
NM_001272082.4 NCBI
GUGCUUCCUGUGGCUGACGUCAUCUGGAGGAGAUUUGCUUUCUUUUUCU… 1789 nt 0.5752
NM_001272083.4 NCBI
GUGCUUCCUGUGGCUGACGUCAUCUGGAGGAGAUUUGCUUUCUUUUUCU… 1963 nt 0.5787
NM_016479.6 NCBI
GGGCGGCCGCGCGGAUCACUGAGGCUGUGGCGGCACUGCGCCCGGCGCU… 2034 nt 0.5939
Summary

This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. Related pseudogenes of this gene are found on chromosome X. [provided by RefSeq, Apr 2016]

Forensic Context

A study in humans demonstrated that the SHISA5 was identified as a high-confidence gene in common between mice and humans within the top 10% of genes related to lifetime alcohol consumption [Farris et al. DOI:10.1038/Mp.2014.159].