Basic Information

Symbol
SIAH1
RNA class
mRNA
Alias
Siah E3 Ubiquitin Protein Ligase 1 RING-Type E3 Ubiquitin Transferase SIAH1 E3 Ubiquitin-Protein Ligase SIAH1 Seven In Absentia Homolog 1 Siah-1a HSIAH1 Seven In Absentia Homolog 1 (Drosophila) EC 2.3.2.27 EC 6.3.2 HUMSIAH BURHAS SIAH1A Siah-1
Location (GRCh38)
16:48356364-48448402
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003031.4
Sequence length
2110.0 nt
GC content
0.4218

Transcripts

ID Sequence Length GC content
NM_001006610.2 NCBI
GCAGUAACUCUUGAGCUGGCUCAGGGAGCGCACUUCCUUCUCAGCCAGC… 2401 nt 0.4136
NM_003031.4 NCBI
GAGGACGCGCGAAACGGCGGCGGCGGCGGCGGCCAGGGGGGAGCCGGGG… 2110 nt 0.4218
Summary

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the SIAH1 in microglia, which is involved in the ubiquitin-mediated proteolysis pathway [Oladapo et al. DOI:10.3390/Ijms26020649]. Another study in mice showed that adolescent exposure to MDMA induces comprehensive transcriptional changes in the cerebral cortex, where the SIAH1 is upregulated as part of the altered Wnt signaling pathway [Eun et al. DOI:10.1016/J.Taap.2009.02.027].