Basic Information

Symbol
SIGLEC1
RNA class
mRNA
Alias
Sialic Acid Binding Ig Like Lectin 1 Sialoadhesin SIGLEC-1 CD169 SN Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin DJ1009E24.1 FLJ00051 FLJ00055 FLJ00073 FLJ32150 Sialic Acid-Binding Immunoglobulin-Like Lectin 1 Sialic Acid-Binding Ig-Like Lectin 1 CD169 Antigen Siglec-1
Location (GRCh38)
20:3686970-3712647
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_023068.4
Sequence length
6960.0 nt
GC content
0.6075

Transcripts

ID Sequence Length GC content
NM_001367089.1 NCBI
GUGCUGGGGCUAAAGUGCCCAGAGGUGUCCCUGGAGGCCCCUGUGAGCC… 6753 nt 0.6077
NM_023068.4 NCBI
GAUACGGGAUCCUUCUCUCUUGAGCCGGCAGAGCCCUGGGGAGCCAGCU… 6960 nt 0.6075
Summary

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection. [provided by RefSeq, Dec 2021]

Forensic Context

A study in humans identified ENST00000344754.5 as an mRNA diagnostic biomarker for acute myocardial infarction, showing it was upregulated in ST-elevation myocardial infarction patients compared to non-ST-elevation myocardial infarction patients with a fold change of 6.83 [Zhong et al. DOI:10.1097/MD.0000000000013066].