Basic Information

Symbol
SIGLEC7
RNA class
mRNA
Alias
Sialic Acid Binding Ig Like Lectin 7 P75/AIRM1 SIGLEC-7 CD328 QA79 Sialic Acid-Binding Ig-Like Lectin 7 QA79 Membrane Protein SIGLEC19P D-Siglec SIGLECP2 AIRM-1 CDw328 AIRM1 P75 Sialic Acid Binding Ig-Like Lectin 19, Pseudogene Adhesion Inhibitory Receptor Molecule 1, Siglec-7 Sialic Acid Binding Ig-Like Lectin, Pseudogene 2 Sialic Acid Binding Immunoglobulin-Like Lectin 7 Adhesion Inhibitory Receptor Molecule 1 Sialic Acid Binding Ig-Like Lectin 7 CD328 Antigen Siglec-7
Location (GRCh38)
19:51142288-51153658
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Mechanical injury analysis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014385.4
Sequence length
1754.0 nt
GC content
0.5587

Transcripts

ID Sequence Length GC content
NM_001277201.2 NCBI
GCAGUUCCUGAGAGAAGAACCCUGAGGAACAGACGUUCCCUCGCGGCCC… 966 nt 0.5280
NM_014385.4 NCBI
GCAGUUCCUGAGAGAAGAACCCUGAGGAACAGACGUUCCCUCGCGGCCC… 1754 nt 0.5587
NM_016543.4 NCBI
GCAGUUCCUGAGAGAAGAACCCUGAGGAACAGACGUUCCCUCGCGGCCC… 1475 nt 0.5437
Summary

Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans using Summary data-based Mendelian randomization analysis of GWAS data from 456,348 European samples identified the SIGLEC7 as having expression levels pleiotropically associated with sepsis, noting it is an important negative regulator of acute inflammatory responses and a potential therapeutic target for the condition [Yang et al. DOI:10.1111/jcmm.18559]. A meta-analysis of human mild traumatic brain injury (mTBI) patients identified the SIGLEC7 as a key hub protein within a neurodegeneration-associated interaction network, where its deficiency is associated with poorer TBI outcome [Matyasova et al. DOI:10.4149/gpb_2021038]. A separate single-cell transcriptomic study in a rat model of radiation-induced lung injury identified the orthologous rat gene *Tnfrsf1b* as being associated with inflammatory processes [Shi et al. DOI:10.17305/bb.2024.10357].