Basic Information

Symbol
SIGMAR1
RNA class
mRNA
Alias
Sigma Non-Opioid Intracellular Receptor 1 SR-BP1 OPRS1 Aging-Associated Gene 8 Protein Sigma 1-Type Opioid Receptor HSigmaR1 Sigma1R SIG-1R SR-BP SRBP SR31747 Binding Protein 1 Opioid Receptor, Sigma 1 SR31747-Binding Protein Sigma1-Receptor ALS16 DSMA2 HMNR2
Location (GRCh38)
9:34634720-34637844
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005866.4
Sequence length
1672.0 nt
GC content
0.5885

Transcripts

ID Sequence Length GC content
NM_001282205.2 NCBI
GUGGGCAGCCGGCGGGCUCCGAGGCCGUGAGCGCAAAGCCUCAGGCCCC… 1454 nt 0.5832
NM_001282206.2 NCBI
GUGGGCAGCCGGCGGGCUCCGAGGCCGUGAGCGCAAAGCCUCAGGCCCC… 1625 nt 0.5852
NM_001282207.2 NCBI
GUGGGCAGCCGGCGGGCUCCGAGGCCGUGAGCGCAAAGCCUCAGGCCCC… 1612 nt 0.5875
NM_001282208.2 NCBI
GUGGGCAGCCGGCGGGCUCCGAGGCCGUGAGCGCAAAGCCUCAGGCCCC… 1695 nt 0.5870
NM_001282209.2 NCBI
GUGGGCAGCCGGCGGGCUCCGAGGCCGUGAGCGCAAAGCCUCAGGCCCC… 1532 nt 0.5862
NM_005866.4 NCBI
GUGGGCAGCCGGCGGGCUCCGAGGCCGUGAGCGCAAAGCCUCAGGCCCC… 1672 nt 0.5885
NM_147157.3 NCBI
GUGGGCAGCCGGCGGGCUCCGAGGCCGUGAGCGCAAAGCCUCAGGCCCC… 1579 nt 0.5896
Summary

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013]

Forensic Context

A study in mice demonstrated that methamphetamine or LPS administration increased SIGMAR1 expression in astrocytes, which was associated with astrocyte activation, autophagy induction, and ER stress [Huang et al. DOI:10.1080/15548627.2017.1356975].