Basic Information

Symbol
SIM2
RNA class
mRNA
Alias
SIM BHLH Transcription Factor 2 BHLHe15 Single-Minded Family BHLH Transcription Factor 2 Class E Basic Helix-Loop-Helix Protein 15 Transcription Factor SIM2 Single-Minded Homolog 2 MGC119447 SIM Single-Minded (Drosophila) Homolog 2 Single-Minded Homolog 2 (Drosophila) HMC13F06 HMC29C01 BHLHE15
Location (GRCh38)
21:36699115-36749917
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005069.6
Sequence length
4461.0 nt
GC content
0.5721

Transcripts

ID Sequence Length GC content
NM_005069.6 NCBI
AUAAACAAACGCGGCUCGGCCGCACGUGGACAGCGGAGGUGCUGCGCCU… 4461 nt 0.5721
NM_009586.5 NCBI
AUAAACAAACGCGGCUCGGCCGCACGUGGACAGCGGAGGUGCUGCGCCU… 3396 nt 0.5898
Summary

This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Forensic Context

A study in mice demonstrated that the SIM2 transcript, a gene encoding a midline development transcription factor, exhibited a significant increase in abundance within 0.5 hours postmortem [Pozhitkov et al. DOI:10.1098/rsob.160267].