Basic Information

Symbol
SIRPA
RNA class
mRNA
Alias
Signal Regulatory Protein Alpha SHPS1 SIRP BIT P84 MFR SHPS-1 CD172a PTPNS1 MYD-1 Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1 CD172 Antigen-Like Family Member A Inhibitory Receptor SHPS-1 Macrophage Fusion Receptor SIRP-ALPHA-1 SIRPalpha2 SIRPalpha MYD1 Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs Brain Ig-Like Molecule With Tyrosine-Based Activation Motifs Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1 Tyrosine Phosphatase SHP Substrate 1 Signal-Regulatory Protein Alpha-1 Signal-Regulatory Protein Alpha-2 Signal-Regulatory Protein Alpha-3 Signal-Regulatory Protein Alpha SHP Substrate 1 CD172a Antigen Myd-1 Antigen MyD-1 Antigen Sirp-Alpha-1 Sirp-Alpha-2 Sirp-Alpha-3 Bit
Location (GRCh38)
20:1892726-1940592
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001040023.2
Sequence length
4580.0 nt
GC content
0.5465

Transcripts

ID Sequence Length GC content
NM_001040022.1 NCBI
UCCGGCCCGCACCCACCCCCAAGAGGGGCCUUCAGCUUUGGGGCUCAGA… 4201 nt 0.5663
NM_001040023.2 NCBI
ACUCACGGCCGCUCUCCCUCCUCGCUCCGCAGCCGCGGCCCAUGGAGCC… 4580 nt 0.5465
NM_001330728.1 NCBI
UCCGGCCCGCACCCACCCCCAAGAGGGGCCUUCAGCUUUGGGGCUCAGA… 4213 nt 0.5661
NM_080792.3 NCBI
GCAGCCCUCGCUCCCUCCCCCGGGGCGCGCAGGCGGGCGCUCGCUCGCA… 4603 nt 0.5483
Summary

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A review of multi-omics studies for human biological age estimation, which synthesizes findings from various human cohorts, identifies the SIRPA as a proteomic aging biomarker with higher abundance in the age-dependent urine proteome of healthy men [Solovev et al. DOI:10.1016/j.mad.2019.111192]. A study in rats demonstrated that the SIRPA (protein tyrosine phosphatase, non-receptor type substrate 1) exhibited significantly altered expression in liver tissue on day 7 following a 20% total body surface area burn injury, where it was functionally associated with innate immune function [Jayaraman et al. DOI:10.1016/j.jss.2007.05.025].