Basic Information

Symbol
SIRT4
RNA class
mRNA
Alias
Sirtuin 4 SIR2L4 NAD-Dependent Protein Lipoamidase Sirtuin-4, Mitochondrial NAD-Dependent ADP-Ribosyltransferase Sirtuin-4 NAD-Dependent Protein Biotinylase Sirtuin-4 NAD-Dependent Protein Deacetylase Sirtuin-4 Regulatory Protein SIR2 Homolog 4 SIR2-Like Protein 4 Sirtuin (Silent Mating Type Information Regulation 2, S. Cerevisiae, Homolog) 4 Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 4 (S. Cerevisiae) Sirtuin Type 4 EC 2.3.1.286 Sir2-Like 4 EC 2.3.1.- EC 2.4.2.-
Location (GRCh38)
12:120292162-120313249
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012240.3
Sequence length
1217.0 nt
GC content
0.5127

Transcripts

ID Sequence Length GC content
NM_001385733.1 NCBI
AAAAAUUGCCAAUGCCGACUAUAUUUCAAGUCGUCAUGGCGGGGUAUUG… 2322 nt 0.5108
NM_001385734.1 NCBI
GCAAAUGCAAUCAGACGGUCCCACUGUGGGGUGUGAAGUGUCCGUAGAG… 944 nt 0.4926
NM_001385735.1 NCBI
AAAAAUUGCCAAUGCCGACUAUAUUUCAAGUCGUCAUGGCGGGGUAUUG… 2049 nt 0.5012
NM_012240.3 NCBI
GCAAAUGCAAUCAGACGGUCCCACUGUGGGGUGUGAAGUGUCCGUAGAG… 1217 nt 0.5127
Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that the SIRT4 mRNA is a predicted target of the upregulated miRNA miR-339-5p and shows anticorrelated expression (Pearson r = -0.78) in left ventricular myocardium following acute ischemia during cardiac surgery [Saddic et al. DOI:10.1152/physiolgenomics.00049.2015]. In a separate human study of monozygotic twins, the SIRT4 expression was undetectable in subcutaneous adipose tissue samples from both heavier and leaner co-twins [Jukarainen et al. DOI:10.1210/jc.2015-3095].