Basic Information

Symbol
SIX3
RNA class
mRNA
Alias
SIX Homeobox 3 Sine Oculis Homeobox Homolog 3 Homeobox Protein SIX3 HPE2 Sine Oculis Homeobox Homolog 3 (Drosophila) Holoprosencephaly 2, Alobar Or Semilobar Sine Oculis Homeobox-Like Protein 3
Location (GRCh38)
2:44941702-44946071
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005413.4
Sequence length
2713.0 nt
GC content
0.5415

Transcripts

ID Sequence Length GC content
NM_005413.4 NCBI
GCACUCACUGUGGAUUUAGGGGAGAUAUUAUGAGGCUGUUGUCAUUAGG… 2713 nt 0.5415
Summary

This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]

Forensic Context

A study in humans demonstrated that the SIX3 was identified as a high-confidence gene in common between mice and humans within the top 10% of genes related to lifetime alcohol consumption through transcriptional network analysis of postmortem prefrontal cortex [Farris et al. DOI:10.1038/Mp.2014.159].