Basic Information

Symbol
SKAP1
RNA class
mRNA
Alias
Src Kinase Associated Phosphoprotein 1 SKAP55 SCAP1 Src Kinase-Associated Phosphoprotein Of 55 KDa Src Kinase-Associated Phosphoprotein 1 Src Family-Associated Phosphoprotein 1 SKAP-55 Pp55 Epididymis Secretory Sperm Binding Protein Li 81p Src Family Associated Phosphoprotein 1 HEL-S-81p
Location (GRCh38)
17:48133437-48430275
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003726.4
Sequence length
1556.0 nt
GC content
0.4955

Transcripts

ID Sequence Length GC content
NM_001075099.2 NCBI
ACAGGUGCCUCGCGGUGCAGCCGGGUCGCCUUCCAGCCCGUCCGCCUCC… 1553 nt 0.4958
NM_003726.4 NCBI
ACAGGUGCCUCGCGGUGCAGCCGGGUCGCCUUCCAGCCCGUCCGCCUCC… 1556 nt 0.4955
Summary

This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans identified the SKAP1 (SKAP1) as a key prognostic biomarker for immunosuppression in severe burn patients via weighted gene co-expression network analysis, LASSO, and logistic regression [Zhang et al. DOI:10.3389/fgene.2022.908510].