Basic Information

Symbol
SKP1
RNA class
mRNA
Alias
S-Phase Kinase Associated Protein 1 TCEB1L OCP-II EMC19 OCP2 P19A SKP1A Transcription Elongation Factor B Polypeptide 1-Like Cyclin-A/CDK2-Associated Protein P19 S-Phase Kinase-Associated Protein 1 Organ Of Corti Protein II Organ Of Corti Protein 2 MGC34403 P19skp1 OCP-2 SIII RNA Polymerase II Elongation Factor-Like Protein OCP2 RNA Polymerase II Elongation Factor-Like Protein S-Phase Kinase-Associated Protein 1A (P19A) Cyclin A/CDK2-Associated P19
Location (GRCh38)
5:134148935-134177029
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_170679.3
Sequence length
9386.0 nt
GC content
0.4120

Transcripts

ID Sequence Length GC content
NM_006930.4 NCBI
GCUGUAGUGGCUUCGUCUUCGGUUUUUCUCUUCCUUCGCUAACGCCUCC… 2616 nt 0.3723
NM_170679.3 NCBI
GCUGUAGUGGCUUCGUCUUCGGUUUUUCUCUUCCUUCGCUAACGCCUCC… 9386 nt 0.4120
Summary

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]

Forensic Context

No relevant information is available at the moment.