Basic Information

Symbol
SLC13A3
RNA class
mRNA
Alias
Solute Carrier Family 13 Member 3 NADC3 SDCT2 Na(+)-Coupled Carboxylate Transporter 3 Na(+)/Dicarboxylate Cotransporter 3 HNaDC3 NaDC-3 NaC3 Solute Carrier Family 13 (Sodium-Dependent Dicarboxylate Transporter), Member 3 Sodium-Dependent High Affinity Dicarboxylate Transporter 3 Sodium-Dependent High-Affinity Dicarboxylate Transporter 2 ARLIAK
Location (GRCh38)
20:46557823-46684467
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_022829.6
Sequence length
4041.0 nt
GC content
0.5236

Transcripts

ID Sequence Length GC content
NM_001011554.3 NCBI
ACUUCCUGCUGCCACGUGGAGAAGGGUGUGUUUGUUUCCCCAUCUGCCA… 4079 nt 0.5158
NM_001193339.2 NCBI
AGUCCCGGGCCGGCCCGUACCGCCAGGCGAUCGCGCUGAUGGCGGCGCU… 3891 nt 0.5230
NM_001193340.2 NCBI
ACUUCCUGCUGCCACGUGGAGAAGGGUGUGUUUGUUUCCCCAUCUGCCA… 3974 nt 0.5148
NM_001193342.2 NCBI
AGUCCCGGGCCGGCCCGUACCGCCAGGCGAUCGCGCUGAUGGCGGCGCU… 3868 nt 0.5199
NM_022829.6 NCBI
AGUCCCGGGCCGGCCCGUACCGCCAGGCGAUCGCGCUGAUGGCGGCGCU… 4041 nt 0.5236
Summary

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans developed a multiplex mRNA assay for organ tissue identification, where the SLC13A3 was initially considered as a candidate marker for kidney tissue but was not mentioned in the introduction or discussion and was not studied further in the experimental selection rounds [Lindenbergh et al. DOI:10.1007/s00414-013-0895-7].