Basic Information

Symbol
SLC16A3
RNA class
mRNA
Alias
Solute Carrier Family 16 Member 3 MCT3 MCT4 Solute Carrier Family 16, Member 3 (Monocarboxylic Acid Transporter 4) Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 3 Solute Carrier Family 16 (Monocarboxylate Transporter), Member 3 Monocarboxylate Transporter 4 MCT 4 Monocarboxylate Transporter 3 MCT 3 MCT-3 MCT-4
Location (GRCh38)
17:82217878-82261129
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004207.4
Sequence length
2599.0 nt
GC content
0.6472

Transcripts

ID Sequence Length GC content
NM_001042422.3 NCBI
GAGGCCGUGCCCCACAUCCAGGCAGCGCAGGCCGCGGGCCGCUCCCCUA… 2629 nt 0.6470
NM_001042423.3 NCBI
AGUCAGUUAGGUAACAGGCCACGGGCCCCGGGCUCAGGCCACUGCACGG… 2662 nt 0.6450
NM_001206950.2 NCBI
GAGGCCGUGCCCCACAUCCAGGCAGCGCAGGCCGCGGGCCGCUCCCCUA… 2645 nt 0.6469
NM_001206951.2 NCBI
CUGCUGCUGCCUCCCAGGGCGCUGGUUCACAGCACGGUCCCAGCAGGGA… 2636 nt 0.6434
NM_001206952.2 NCBI
AGUGCAGAGGGAGUGGGACCCACAGCUGCUAGCCUCCCUCCAAACCCUC… 2603 nt 0.6427
NM_004207.4 NCBI
GGCAGAGGCGGGCAGAGGCGGCGAGAGGCGGCGAGAGGCGGGCUGAGGC… 2599 nt 0.6472
Summary

Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]

Forensic Context

A study in rhesus macaques identified the SLC16A3 as a differentially expressed gene upregulated in animals with hypertrophic cardiomyopathy, where its expression pattern was better modeled by including age as a factor alongside disease condition [Rivas et al. DOI:10.1038/s41598-024-82770-4].